GALAB Biotechnology
GALAB Biotechnology – Next level biocatalysis
GALAB Biotechnology is specialised in the biocatalysis of valuable products for a broad range of industrial applications. One of our main focused products are human milk oligosaccharides (HMOs). Our interdisciplinary experts develop customised bioprocesses with synthetic biology and complex multi-enzyme cascades for sustainable and high yield productions. Moreover, with our GlycoKat® and NucleoKat® technologies we provide innovative, high-quality products and services for our customers.
Synthetic Biology for in vivo production processes
We apply synthetic biology and metabolic engineering for precise modifications of cells to initiate and enhance the production of target compounds. One of our competencies at GALAB Biotechnology is the in vivo synthesis of valuable HMOs with our patented strains. Our engineered Corynebacterium glutamicum and Escherichia coli strains produce high titer of fucosyllactose and sialyllactose. CRISPR/Cas9 is one of our powerful tools for precise genome editing and modifying metabolic pathways. It allows the fast addition of new genes, modification of existing genes or the knockout of specific genes to optimize the synthesis of our target products.
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In vitro synthesis – from genes over stable biocatalysts to products
We offer a complete process development service for in vitro synthesis, from genes to products. Our proprietary expression strains are used in high cell density fermentation, which have been developed and optimised over the last 10 years to achieve high enzyme yields. In order to develop a tailor-made production process for each enzyme, we offer a variety of enzyme purification and preservation methods. Furthermore, our unique enzyme immobilisation technology enables us to produce highly stable enzymes that can be used in different reactor systems. We have developed a technology that simplifies the implementation of multi-enzyme cascades by using our stable immobilised enzymes in packed bed reactors in continuous flow reactor setups.
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Modular process design – GlycoKat® and NucleoKat®
Modular process design makes it easy to implement multi-enzyme cascades. Our GlycoKat® technology enables the continuous synthesis of a wide range of glycosylated oligosaccharides, with simple product changes by replacing individual modules. The addition of our NucleoKat® technology takes glycosylation to a whole new level. The NucleoKat® technology is a module that enables the regeneration of expensive nucleotide cofactors and can be integrated into other processes for all types of nucleotides.
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Services and expertise:
- Synthetic Biology to produce HMOs in efficient E. coli and C. glutamicum strains
- CRISPR/Cas9 technology for precise genome editing and modifying metabolic pathways
- Production of pure, active, and stable biocatalysts through formulation- and immobilization techniques
- Process development in different reactor concepts, e. g. continuous flow operation with packed bed reactors
- Model development of multi-enzyme cascades
- GlycoKat® and NucleoKat® modular technology for efficient synthesis and cofactor regeneration
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